Full-chain mtDNA scavenging
A co-assembled nanosystem that modulates mitochondrial DNA levels via multiple modes to block the cGAS-STING inflammatory pathway and promote chronic wound healing.
Xueyan, Mao · Shufan, Yu · Zhang, Kai · Wang, Zheng · Du, Jing · Kong, Ying · Bianco, Alberto · Ge, Shaohua · Ma, Baojin
Biomaterials 2026
Significantly inhibited activation of the mtDNA-mediated cGAS-STING pathway
Relieved release of inflammatory factors
Promoted anti-inflammatory phenotype polarization of macrophages
Accelerated chronic wound healing