Reverse regioselectivity
This catalytic system enables enantioselective arylalkylation of alkenes with regioselectivity opposite to the classical radical relay strategy, offering a new tool for modular synthesis of bioactive molecules.
Zhan, Dong · Changyu, Xu · Jianchao, Chang · Sitian, Zhou · Sun, Peipei · Li, Yuqiang · Chen, Liangan
ACS Catalysis 2024
Effective for both terminal and internal alkenes
Exquisite control of regio-, chemo-, and stereoselectivity
Compatible with bioactive motifs
Mild reaction conditions