BMP4 thermosensitive hydrogel

Repairs corneal epithelial junctions

A BMP4-loaded F127-OSA hydrogel that gels at ocular surface temperature inhibits corneal neovascularization by repairing apical junctional complexes, outperforming conventional solvent.

Nan, Weijin · Shen, Sitong · Yang, Yongyan · Meiliang, Wu · He, Yuxi · Ruiting, Zhang · Cui, Xuejun · Zhang, Yan

Materials Today Bio 2024

Advantages

14% F127-OSA hydrogel transforms from sol to gel at 31–32°C

Significantly reduces corneal neovascularization length and area

Repairs microvilli, intercellular junctions, and damaged apical junctional complexes