DBDPE Flame Retardant

Neurocognitive Risk Alert

This deliverable provides high-purity decabromodiphenyl ethane (DBDPE) for investigating its mechanism of inducing neurodegeneration-related cognitive impairment in zebrafish, serving as a key material basis for risk assessment of novel brominated flame retardants.

Kaiwen, Hu · Conghui, Shan · Li, Bin · Guo, Mengmeng · Tan, Zhijun · Yang, Shu · Chenhui, Wu · Yu, Yingying · Gao, Yan · Shi, Wei · Liu, Guangxu

Environmental Science & Technology 2026

Specifications

Number of screened NBFRs

{'zh': '27', 'en': '27'}

Predicted toxicity endpoints

{'zh': '2', 'en': '2'}

Number of verified compounds

{'zh': '1', 'en': '1'}

Advantages

Early identification of high-risk substances

Screening-level toxicokinetic and toxicity predictions prioritize 27 NBFRs, guiding subsequent risk management and experimental validation.

Defines neurotoxicity endpoints

Predictions indicate that most investigated NBFRs share neurotoxicity and blood-brain barrier (BBB) toxicity as common endpoints, suggesting widespread neurotoxic potential across this chemical class.

Elucidates ferroptosis mechanism

DBDPE exposure leads to ferroptosis as a major affected process, accompanied by mitochondrial alterations, offering novel mechanistic insights.

Ferroptosis inhibitor alleviates

Ferrostatin-1 (Fer-1) markedly alleviated DBDPE-induced cognitive impairment and most ferroptosis- and mitochondria-related changes, suggesting potential intervention targets.

Applications

• Environmental toxicology research：Supplies zebrafish neurotoxicity data for DBDPE, supporting environmental toxicology studies.
• Chemical risk assessment：Establishes an AOP-informed framework to aid risk assessment and prioritization of NBFRs.
• Neurotoxicity screening：Identifies ferroptosis and Fer-1 intervention as targets for neurotoxicity screening.