Triple blockade of lipid accumulation
Simultaneously restricts extracellular lipid uptake, de novo biosynthesis, and lipogenic gene transcription via Msr1 binding to slim down tumor-associated dendritic cells and restore anti-tumor function.
Ji, Xiaoyuan · Zhou, Yanfeng · Guo, Daoxia · Li, Qian · Chen, Nan · Fan, Chunhai · Song, Haiyun
Advanced Materials 2023
Promotes maturation of tumor-associated dendritic cells
Enhances inflammatory cytokine production
Enhances cytotoxic T cell recruitment
Overcomes tumor resistance to immune checkpoint blockade therapy