IMQ-Derived Liposomal Nanovesicles

Rejuvenates tumor immune responses

IMQ-derived liposomal nanovesicles function as a TME-responsive delivery vehicle, reprogramming macrophages for antitumor immunity and synergizing with immune checkpoint blockade, while enabling personalized tumor antigen delivery.

Huang, Ruijie · Chen, Bo · Zhu, Yang · Chen, Xiaoyuan S. · Min, Yuangzeng

ACS Nano 2023

Advantages

Complete tumor regression in 6/8 of 4T1-bearing mice

Cured mice resisted secondary tumor challenge