Enhance bone repair after transplantation
Mechanical stimulation upregulates periostin expression and induces M2 polarization; transplantation to bone defects significantly enhances repair, offering a new cell therapy for bone regeneration.
Wang, Ziyan · Lin, Minmin · Liu, Yang · Yang, Chengyu · Jianqun, Wu · Wang, Yan · Chen, Rouxi · Liu, Chao
Bone Research 2024
Mechanical stimulation increases periostin expression in macrophages via TGF-β activation and induces M2 polarization
Transplantation of mechanically conditioned macrophages into the periosteum over a bone defect results in substantially enhanced repair