Turns cold tumors hot
A Chlorella-synthesized low-Mn MnSe nanocomposite that effectively activates the cGAS-STING pathway, transforming immunologically cold tumors into hot ones.
Gao, Wenjuan · Wang, Yue · Wang, Peng · Kan, Wenjie · Wang, Xiaofei · Pengjun, Yuan · Ma, Yuhan · Zhang, Jia · Tian, Geng · Zhang, Guilong
Acta Biomaterialia 2024
Produces more ROS than pure Se nanoparticles and free Mn2+ ions at extremely low Mn content
Activates stronger cGAS-STING signaling pathway
Combined with αPD-L1 further enhances anti-tumour immune response
Bio-MnSe@Dox suppresses tumor relapse and lung metastasis