Thiazolylidene Copper Complex

Pd-free alkynylation

Its unique 'half-umbrella' geometry enables superior performance over conventional imidazolylidenes, achieving a palladium-free Sonogashira coupling.

Zhang, Jin · Hang, Yang · Sun, Li · Yan, Guo · Wang, Ruihong · Szostak, Michal L.

Organic Letters 2025

Advantages

Broad substrate compatibility and functional group tolerance

Late-stage pharmaceutical alkynylation

Rare alkynylative C-H functionalization/ring-opening pathways

Superior performance over traditional imidazol-2-ylidenes