Augments PD-L1 Immunotherapy
Carbon dots derived from silkworm excrement are integrated into novel tumor-targeting nanomicelles, inducing immunogenic cell death via ferroptosis and photodynamic therapy, while downregulating PD-L1 to potentiate immune checkpoint blockade.
Bao, Yujun · Guanghao, Li · Mingyang, Liu · Siqi, Li · Haishui, Zhou · Ziqing, Yang · Wang, Zhiqiang · Guo, Changhong · Jin, Yingxue
Chemical Engineering Journal 2025
Effectively downregulates PD-L1 expression on tumor cell surfaces
Enhances anti-PD-L1 therapy by inhibiting HIF-1α pathway
Reverses hypoxic tumor microenvironment