ADSL Moonlighting Function

Yuran, Duan; Wang, Shuo; Liu, Jianyu; Yuli, Shen; Yueru, Hou; Xue, Sun; Lin, Yanni; Hu, Zhiqiang; Bofei, Dong; Bi, Yanli; Yang, Huang; Li, Min; Liwei, Xiao; Wu, Qingang; Bai, Xueli; Wang, Yuhao; Ding, Yuan; Mao, Zhengwei; Luo, Yang; Lu, Zhimin; Liu, Tong; Xu, Daqian; Liu, Shijian; Zhan, Pengpeng; Zhang, Wang

ADSL Moonlighting Function

Cancer lipid driver

Reveals a novel moonlighting function of ADSL in succinating INSIG1/2 to activate SREBP-1, and identifies a clinically available inhibitor.

Yuran, Duan · Wang, Shuo · Liu, Jianyu · Yuli, Shen · Yueru, Hou · Xue, Sun · Lin, Yanni · Hu, Zhiqiang · Bofei, Dong · Bi, Yanli · Yang, Huang · Li, Min · Liwei, Xiao · Wu, Qingang · Bai, Xueli · Wang, Yuhao · Ding, Yuan · Mao, Zhengwei · Luo, Yang · Lu, Zhimin · Liu, Tong · Xu, Daqian · Liu, Shijian · Zhan, Pengpeng · Zhang, Wang

Nature Communications 2026

Advantages

ADSL promotes succination of INSIG1/2

Elsulfavirine blocks ADSL-INSIG interaction

ADSL phosphorylation and INSIG succination correlate in HCC