Reprograms Immunity
MSCs trained with TNF-α and IFN-γ restore the immune microenvironment in fulminant hepatic failure mice, recovering liver function and markedly reducing inflammation.
Li, Bingqi · Jiang, Jing · Zhou, Qian · Li, Tong · Liang, Xi · Xin, Jiaojiao · Chen, Xi · Xiao, Wu · Shiwen, Ma · Luo, Jinjin · Wei, Qiang · Zhu, Bing · Luo, Xinhua · Li, Jun · Shi, Dongyan
Stem Cell Research and Therapy 2025
Pro-inflammatory genes IL1β and IL8 significantly upregulated vs untrained (p<0.0001)
Immunoregulatory genes PDL1 and IDO1 significantly upregulated (p<0.0001)
ALT and AST levels significantly improved in treated mice (p<0.01)
Inflammatory cytokines IL6 and MCP1 significantly reduced (p<0.01)