Oral Colitis Relief
A food-grade Lactococcus lactis strain engineered to continuously secrete mouse β-defensin 14 in the gut, overcoming the instability that prevents oral AMP delivery to the colon.
Haizhi, Tian · Li, Jiahong · Chen, Xiaopei · Ren, Zhengnan · Pan, Xiaohua · Huang, Weining · Bhatia, Madhav · Pan, Lilong · Sun, Jia
Journal of Agricultural and Food Chemistry 2023
Colitis symptoms significantly alleviated (P < 0.01)
Pro-inflammatory cytokine production reduced (P < 0.01)
NLRP3 inflammasome-mediated pro-inflammatory response inhibited (P < 0.05)
Abundance of probiotic Akkermansia muciniphila and Faecalibacterium prausnitzii increased (P < 0.01)