Rapid Activation, Enhanced Effector Function
Engineered with rapid m6A methylation driven by the mTORC1-SAM axis, these NK cells activate faster and exhibit enhanced antitumor effector functions even in the tumor microenvironment.
Zhang, Meng · Zhong, Zhaoyang · Song, Liang · Tian, Lei · Wu, Wei · Yang, Yao · Deng, Yafei · Peng, Hongyan · Wu, Shuting · Wang, Yang · Li, Xiaohui · Yu, Jianhua · Deng, Youcai
Cancer Immunology Research 2024
m6A methylation levels rapidly upregulated upon short-term NK-cell activation
Double knockout of METTL3/14 significantly impacts NK-cell antitumor immunity
Prf1 and Gzmb directly modified by m6A methylation
mTORC1 inhibition prevents m6A increase, restored by SAM supplementation