Acyclic Twisted Thioamides

Ground-state destabilization enables chemoselective transition-metal-free acylation of thioamides to yield 3-hydroxy-1-thioxoketones.

Zhang, Jin · He, Yang · Zhu, Xinhao · Yan, Guo · Wang, Xiaogang · Wang, Ruihong · Szostak, Michal L.

Organic Chemistry Frontiers 2025