Gallium-flavonoid antimicrobial compound

Dual mechanism kills P. aeruginosa

Disrupts both iron metabolism and quorum sensing, achieving bactericidal activity and biofilm eradication.

He, Xiaojun · Han, Bingjie · Wang, Runming · Guo, Yu · Kao, Richard Yi Tsun · Hongyan, Li · Sun, Hongzhe · Xia, Wei

RSC Chemical Biology 2023

Advantages

significant bactericidal activity

substantially reduce the secretion of virulence factors

eliminate biofilm formation

validated in mammalian cell and murine skin infection models