Tumor-Targeting Hydrogel

Spares normal cells

An ALP-triggered on-cell hydrogel that kills osteosarcoma cells via biomineralization without inducing drug resistance.

Yang, Xiao · Gao, Simin · Yang, Boguang · Yang, Zhilan · Liu, Fang · Huang, Pei · Zhao, Pengchao · Guo, Jiaxin · Fang, Huapan · Chu, Bingyang · He, Miaomiao · Wang, Ning · Chan, Hon Fai · Wang, Zuankai · Bian, Liming · Zhang, Kunyu

Advanced Science 2023

Advantages

Better tumor treatment effect than doxorubicin

Does not harm normal cells

Does not cause multidrug resistance in tumor cells