Sphingomyelin Lipid Raft Nanoparticles

Markedly Enhanced mRNA Uptake

Replacing DSPC with sphingomyelin creates active lipid raft structures that fundamentally alter protein corona composition, offering a novel high-efficiency pathway for mRNA delivery.

Li, Na Na · Li, Hao · Tian, Qiang · Li, Jing · Gao, Peng · Ying, Bo · Wang, Changchun

Journal of Controlled Release 2026

Specifications

Semi-lamellar morphology formed

{'zh': '', 'en': '-20'} mol%

与含

{'zh': '10', 'en': ''} mol% DSPC

Advantages

Enhanced therapeutic efficacy in protein replacement therapy (IV) and prophylactic vaccines (IM)

Broad applicability confirmed with ALC-0315 and lipid 5 ionizable lipids