Mucosal Potent Protection
The ferritin-based nanovaccine, delivered via microneedles, efficiently crosses mucosal barriers and induces secretory IgA and systemic immunity against respiratory pathogens.
He, Chunting · He, Penghui · Ye, Lin · Wang, Yuwei · Guo, Zhaofei · Ou, Yangsen · Wang, Hairui · Zhao, Yuanhao · Bai, Shuting · Hongjiao, Wei · Du, Guangsheng · Sun, Xun
Journal of Controlled Release 2025
Induces potent sIgA production
Activates antigen-presenting cells
Enhances mucosal and systemic humoral and cellular immune responses
Provides effective protection against PA pulmonary infection