Single-Cell Protein-Metabolite Analyzer

First simultaneous quantification

Via exogenous enzymatic signal conversion and amplification, it achieves for the first time simultaneous quantification of endogenous proteins and hundreds of metabolites at the single-cell level.

Yu, Bai · Zhang, Xinyi · Wei, Wensheng

Chemical Science 2025

Advantages

First simultaneous detection of GAPDH and hundreds of metabolites at the single-cell level

Identified 16 metabolites positively correlated with GAPDH expression under oxidative stress, including long-chain fatty acids (palmitoleic acid, myristic acid, etc.) and UDP-N-acetylglucosamine