Iridium Photosensitizer-Engineered Bacteria

Targeting and Penetrating Solid Tumors

Covalently labeling an iridium(III) photosensitizer onto engineered bacteria exploits the bacteria's self-propulsion and hypoxia tropism for selective deep penetration into solid tumors and synergistic photodynamic immunotherapy.

Liu, Yu · He, Xiaojun · Shen, Jianliang · Wang, Mao · Xia, Wei

Angewandte Chemie - International Edition 2023

Advantages

First metal complex-decorated bacteria for enhanced photodynamic immunotherapy

Induces pyroptosis and immunogenic cell death of tumor cells

Remarkably evokes anti-tumor innate and adaptive immune responses in vivo

Leads to regression of solid tumors