Marked lung function improvement
Nebulized MSC-derived EVs target the lungs for non-invasive, safe cell therapy in pulmonary fibrosis.
Li, Meng · Huang, Huaping · Li, Jun · Fang, Xingyue · Wang, Heyu · Li, Mengdi · Lin, Yuting · Wang, Yinyin · Zhao, Tongbiao · Hao, Xinbao · Yan, Muyang · Xu, Lu · Chang, Zhijiec Jie
Signal Transduction and Targeted Therapy 2025
Phase I trial in 24 patients: well tolerated, no serious adverse events
Combined therapy significantly improved FVC and MVV
2 advanced patients showed clinically significant regression on CT