Radiosensitizes melanoma
A multifunctional nanosystem combining photothermal, catalytic, and immunomodulatory functions to overcome radioresistance and enhance radioimmunotherapy of melanoma.
Wang, Wandong · Sun, Weiguo · Kong, Yinghui · Jiang, Guan · Gao, Yong · Gao, Fenglei
Advanced Science 2025
Generates ROS via plasmon-driven catalysis and Mn-mediated Fenton-like reactions under 1064 nm laser irradiation
Mild hyperthermia promotes oxygenation and disrupts DNA repair pathways, leading to multi-directional DNA damage and increased immunogenic cell death (ICD)
Released Mn²⁺ activates the cGAS-STING pathway, synergizing with ICD to promote systemic antitumor immunity