Immunogenic ferroptosis
A dual-action nanocarrier that blocks the GPX4-GSH axis while reversing immunosuppression, enabling combined ferroptosis and immunotherapy for glioma.
Wang, Rui · Xiong, Wei · Wang, Bing · Zhao, Pengfei · Chen, Meiwan · Huang, Yongzhuo · Zhao, Pengfei
Journal of Controlled Release 2024
Significantly prolonged survival of glioma-bearing mice
Effectively enhanced brain accumulation of DDC/Cu-Fe
Synergistically induced ferroptosis and activated anticancer immunity