Across the BBB
A selenium-based nanoassembly stabilized by hydroxyl-rich fingolimod, camouflaged with melanoma cell membrane to cross the blood-brain barrier and target phosphorylated tau, dually alleviating oxidative stress and neuroinflammation in Alzheimer's disease.
Xue, Rui · Zhang, Beibei · Wu, Jin · Zhang, Ningnannan · Sun, Chunyang
Biomaterials 2025
In an okadaic acid-induced AD mouse model, significantly ameliorated spatial learning and memory impairments
PET-CT imaging confirmed the reduction in abnormal tau aggregation following treatment