Metal-free, mild pyrrole synthesis
A metal-free heterogeneous catalyst that enables mild cascade synthesis of N-substituted pyrroles from nitroarenes and 1,4-diketones, with excellent tolerance for sensitive functional groups and no side reactions such as dehalogenation or arene hydrogenation.
Yu, Xiangzhu · Wang, Lianyue
ACS Applied Materials & Interfaces 2024
Compatible with various reducing agents (hydrazine hydrate, formic acid, hydrogen)
Good compatibility with substrates containing sensitive functional groups (halides, esters, cyano)