Oxadiazole-Containing Diarylpyrimidine Derivatives

Anti-Resistant HIV Candidate

Novel diarylpyrimidine derivatives with nanomolar potency against wild-type and NNRTI-resistant strains, and favorable pharmacokinetics.

Zhang, Tao · Yue, Yang · Li, Xin · Zhao, Fabao · Zongji, Zhuo · Wang, Le · Zhang, Wenbo · De Clercq, Erik · Pannecouque, Christophe · Zhan, Peng · Kang, Dongwei · Liu, Xinyong

Journal of Medicinal Chemistry 2025

Specifications

EC

{'zh': '-54.0', 'en': '-54.0'} nM

EC

{'zh': '24.2', 'en': '24.2'} nM

EC

{'zh': '54.0', 'en': '54.0'} nM

口服生物利用度

{'zh': '14.4', 'en': ''} %