C–N transmutated polycyclic arenol skeletons

Direct C-to-N swap in aromatics

Replaces a carbon atom in polycyclic arenol frameworks with nitrogen without altering ring size, yielding diverse N-heteroarenes.

Lu, Hong · Zhang, Yu · Wang, Hong · Zi Ran, Zhang · Xu, Pengfei · Wei, Hao

Nature Communications 2024

Advantages

broad functional group tolerance

streamlined assembly of complex polycyclic heteroaromatics

synthesis of complex biheteroarene skeletons