pH-Responsive Synergistic Thermo-Chemo
A pH-responsive nanosuspension composed of an orthoester, a photothermal agent, and iron oxide nanoparticles that enables tumor microenvironment-triggered drug release and synergistic photothermal and chemodynamic therapy.
Hu, Junjie · Zhang, Chi · Xu, Hao · Yingda, Wan · Wang, Xin · Tang, Rupei
ACS Applied Bio Materials 2025
Acid-sensitive degradation of orthoester enables controlled release in tumor microenvironment
Fe3O4 induces ROS generation via Fenton reaction
Formulation prolongs drug retention in tumor tissues and enhances penetration