Oxygen-Vacancy Enriched Pt Single-Atom Nanozyme

Island-Sea Synergy

Pt single atoms embedded in CeO2-x nanoislands achieve enhanced electron transfer via an island-sea synergistic effect, with catalytic activity markedly exceeding CeO2.

Zhu, Yang · Lv, Zehui · Xuejie, Cai · Penghui, Wei · Wang, Dengliang · Wang, Zhao · Wang, Yingjie · Xingdong, Yang · Bian, Yixin · Jiawei, Xu · Weng, Xisheng · Wei, Liangfeng

Advanced Science 2026

Advantages

Higher catalytic activity

The island-sea synergistic effect facilitates strong electron transfer, endowing CeO2-x/Pt SANI with markedly higher catalytic activity than CeO2.

More oxygen vacancies

Pt incorporation increases oxygen vacancies and tunes the d-band center toward the Fermi level, facilitating ROS adsorption and accelerating redox reactions.

Reprograms oxidative microenvironment

Single-cell sequencing and experimental results confirm that CeO2-x/Pt SANI reprograms the oxidative microenvironment, leading to significant therapeutic effects in SONFH.

Applications

• Osteonecrosis Therapy：Reprograms the oxidative microenvironment to repair steroid-induced osteonecrosis.
• Antioxidant Nanozymes：Mimics natural enzymes to scavenge ROS with superior activity over CeO2.
• ROS Scavenging Materials：Facilitates ROS adsorption and accelerates redox reactions.