Cu5.4O Nanozyme Hydrogel

pH-sequential antibiofilm and healing

This hydrogel switches from synergistic antibacterial/antibiofilm action at acidic pH to antioxidant/regenerative promotion at neutral pH.

Chen, Yang · Liu, Zhicheng · Li, Ting · Hao, Zhang · Wei, Haicheng · Meng, Lingjie · Jing, Xunan · Guan, Hao

Bioactive Materials 2026

Specifications

Biofilm dispersal rate

{'zh': '87.46', 'en': '87.46'} %

Wound closure rate

{'zh': '91.65', 'en': '91.65'} %

CD31+ cells per field

{'zh': '90', 'en': '90'}

CD163+ cells per field

{'zh': '110', 'en': '110'}

Advantages

>99.99% MRSA and E. coli eradication

87.46% biofilm dispersal rate

>90% ROS scavenging

91.65% wound closure within 7 days

~90 CD31+ cells/field

~110 CD163+ cells/field

Applications

• Infected wound dressing：Auto-sterilizes and debrides in infection, then promotes regeneration without dressing change.
• Responsive drug delivery：pH-triggered HAs shell controls Cu5.4O release for on-demand therapy.
• Smart antibacterial materials：Synergistic CDT/PTT with microenvironment-responsive precision killing.
• Chronic wound care：Scavenges ROS and promotes M2 polarization to break the chronic inflammation cycle.
• Bacterial infection theranostics：Integrates killing (therapy) and microenvironment sensing (diagnostic signal) in one platform.