Mo5N6 Nanozyme

Multi-enzyme mimetic for periodontitis

A multi-enzyme mimetic nanozyme with peroxidase-, oxidase-, and catalase-like activities that treats periodontitis by regulating ROS and remodeling the microbiome.

Weiyu, Zhang · Yang, Zhongwei · Zhang, Yunfan · Wang, Longwei · Zhang, Xiaoyu · Yizhi, Dai · Yifan, Yuan · Mingge, Wang · Xin-Xin, Yang · Yu, Xin · Liu, Jing · Chen, Chunying

Advanced Science 2026

Advantages

Dual action: bactericidal yet safe

Multi-enzyme activity kills bacteria via ROS while CAT-like activity scavenges excess ROS, preventing oxidative damage to host tissue.

Targets anaerobic pathogens

Effectively suppresses anaerobic Gram-negative periodontal pathogens that are sensitive to elevated ROS, while sparing aerobic commensals, thus promoting microbiome restoration.

Promotes tissue regeneration

By attenuating pathogenic stimuli and improving the microenvironment, it facilitates restoration of commensal microbiota and regeneration of periodontal tissues.

Applications

• Periodontitis therapy：Used as a local therapeutic in periodontal pockets to replace or supplement antibiotics, reducing antimicrobial resistance.
• Oral pathogen detection：Its peroxidase-like activity enables colorimetric detection of oral pathogens via chromogenic reactions.
• Bacterial sensing：Acts as a nanozyme sensing element that amplifies signals via ROS to detect bacterial activity or metabolites.
• Oral drug delivery：Can be incorporated into gels or microparticles for sustained release in periodontal pockets while retaining enzyme activity.