Size-dependent renal clearance
The lateral dimension dictates renal excretion route and injury site: small sheets undergo glomerular filtration while large sheets undergo faster tubular secretion.
Chen, Wei · Wang, Bing · Liang, Shanshan · Meng, Wang · Zheng, Lingna · Si, Xu · Jiali, Wang · Fang, Hao · Yang, Pu · Feng, Weiyue
Journal of Nanobiotechnology 2023
Large GOs cleared via proximal tubular secretion at a much faster rate than small GOs cleared via glomerular filtration
At 15 mg/kg, small GOs induced glomerular podocyte injury; large GOs induced tubular epithelial necrosis, brush border loss, cast formation, and tubular dilatation
Large GO-treated mice showed elevated mRNA levels of tubular injury biomarkers KIM1 and NGAL
Dose-dependent increase in basolateral organic anion transporters Oat1 and Oat2 mRNA levels in kidneys of large GO-treated mice