Pt(IV)-Indomethacin Nanoparticles

Amplifies pyroptosis

Co-delivers Pt(IV) prodrug and COX-2 inhibitor, amplifying chemotherapy-induced pyroptosis and activating antitumor immunity.

Wang, Yushu · Tang, Yujing · Huang, Jia · Xiao, Haihua · Liu, Chaoyong · Yu, Yingjie · Yang, Zhiying

Advanced Materials 2023

Advantages

Significantly inhibit tumor growth

Completely suppress metastatic tumors when combined with α-PD-L1