Pd–BIAN–NHC Chloro Dimer

Air-stable High Activity

Combines the high reactivity of Pd chloro dimers with the structural rigidity of BIAN–NHC, enabling efficient C–N coupling of challenging substrates.

Zhang, Jin · Jianglong, Cai · Li, Xue · Zhang, Gaopeng · Yan, Wenxuan · Renjie, Li · Tong, Jianbo · Szostak, Michal L.

Journal of Catalysis 2024

Advantages

59 examples, including challenging substrates, diamination, and direct functionalization of pharmaceuticals

fast activation under both inert atmosphere and aerobic conditions

most reactive Pd(II)–NHC precatalyst to date

air-stable