Bifunctional oxime ester reagent

One-step access to 1,6-amino alcohols

This bifunctional reagent generates alkoxy radicals gently via visible-light-induced energy transfer, and through 1,5-HAT and alkene alkylamination, constructs 1,6-amino alcohols that are difficult to access by traditional methods in one step, with broad functional group tolerance.

Du, Xiaohua

Chemical Communications 2024

Advantages

One-step construction of 1,6-amino alcohols via 1,5-HAT-mediated difunctionalization

Mild generation of alkoxy radicals via visible light-induced energy transfer

Hypervalent iodine reagent as oxidant