Oral CBLB Inhibitor

Immuno-Oncology

An orally available small-molecule CBLB inhibitor showing efficacy alone and synergy with anti-PD-1, inducing durable immune memory.

Aliper, Alexander M. · Ren, Feng · Ding, Xiao · Zhavoronkov, Alex A.

Journal of Medicinal Chemistry 2025

Advantages

Potent CBLB inhibition in vitro and in vivo

Strong synergy with anti-PD-1 to enhance tumor regression

Induced durable immune memory against tumor rechallenge

Favorable oral bioavailability and ADME properties