Targeted anti-angiogenesis
An antitumor peptide conjugate that induces endothelial cell apoptosis via the mitochondria-mediated pathway, with targeting and prolonged half-life.
Li, Yan · Huiwen, Hou · Tang, Wen · Zengmei, Liu · Didi, Gao · Feiyan, Zhao · Xinqing, Gao · Sun, Feng · Tan, Haining
International Journal of Biological Macromolecules 2024
Stability was superior to EA at different temperatures and pH ranges
Induced cell apoptosis via downregulating Bcl-2, reducing mitochondrial membrane potential, upregulating cytochrome c, Caspase 3, and reactive oxygen species levels
Did not cause any harmful effects on vital organs of mice