Temperature/pH dual-responsive
An injectable self-healing hydrogel based on orotic acid-modified chitosan, crosslinked via hydrogen bonds and π-π interactions, enabling precise drug release in response to gastrointestinal temperature and pH changes.
Yang, Yongyan · Feng, Gangying · Wang, Jingfei · Ruiting, Zhang · Zhong, Shuangling · Jia, Wang · Cui, Xuejun
International Journal of Biological Macromolecules 2023
Thermoreversible gelation
pH-responsive release
Self-healing