Chiral Polycyclic Pyrroles

Excellent Enantioselectivity

Copper-catalyzed diyne cyclization enables enantioselective insertion into unactivated C(sp3)-H bonds via kinetic resolution, providing efficient access to chiral polycyclic pyrroles.

Chen, Bo · Gao, Liu · Wang, Zhe · Chang, Rong · Lu, Xin · Zhou, Bo · Ye, Longwu

Nature Communications 2024

Advantages

Excellent enantioselectivities

Selectivity factor up to 750