Quinazoline-Fused Imidazole-Thione Derivatives

One-pot tetrasubstituted carbon center

Constructs four C–N bonds, two rings, and a hydroxy-bearing tetrasubstituted carbon center in one pot via a three-component bicyclization, with derivatizable products.

Jiaao, Xue · Kewei, Hu · Duoluo, Guo · Jinxing, Zhang · Cai, Qun

Tetrahedron 2026

Advantages

Forms 4 new C–N bonds in one pot

Constructs 2 rings

Builds 1 tetrasubstituted carbon center with a hydroxy group