Hypoxia-tolerant Type-I PDT
The first heptamethine cyanine type-I photosensitizer capable of both H-abstraction and electron transfer, inducing autophagy, necrosis, and ferroptosis in hypoxic tumors.
Fuping, Han · Zhou, Xiao · Zhang, Zhenyu · Hongyi, Zhang · Li, Xin · Shi, Tiancong · Long, Saran · Sun, Wen · Du, Jianjun · Fan, Jiangli · Peng, Xiaojun
Angewandte Chemie - International Edition 2025
Exhibits bright fluorescence
Generates hydroxyl and alkyl radicals upon NIR irradiation
Induces mitochondrial autophagy in hypoxic tumor cells
Significantly inhibits solid tumor growth