Ni-Catalyzed Lactone Si-Swap

CO to Si in One Step

A nickel catalyst swaps the carbonyl of lactones for silicon, directly yielding silacyclic building blocks without de novo synthesis.

Zhang, Yu · Zheng, Zhaojing · Lu, Hong · Wei, Hao

Angewandte Chemie - International Edition 2025

Advantages

Applicable to coumarins, isocoumarins, dibenzopyranones, and other lactones

Enables late-stage skeletal editing of pharmaceutical and natural product derivatives

Silacycle products undergo further derivatization