FabH Inhibitory Antibacterial Agent

Potent and Low Toxicity

Targeting FabH to inhibit bacterial fatty acid synthesis, compound 25 exhibits potent antibacterial activity at low concentrations and promotes healing of infected wounds.

Chang, Haoyun · Zhu, Zhiyu · Wang, Yapin · He, Dan · Huang, Peng · Wang, Rui · Zhou, Yang

European Journal of Medicinal Chemistry 2023

Specifications

MIC range

{'zh': '-3.13', 'en': '-3.13'} μg/mL

FabH IC

{'zh': '2.0', 'en': ''} μM

天感染伤口愈合率

{'zh': '94', 'en': ''} %