Enhanced cellular immunity
A gE mRNA vaccine delivered by SM-102 lipid nanoparticles that induces superior cell-mediated immunity in prime-boost regimens compared to a protein subunit vaccine.
Li, Dongdong · Bian, Lijun · Cui, Lili · Jingying, Zhou · Li, Gaotian · Sun, Bo · Jiang, Chunlai · Kong, Wei · Zhang, Yong · Chen, Yan
International journal of nanomedicine 2024
2×RNA-gE or RNA-gE>PS-gE groups showed lower IgG1/IgG2c ratio than 2×PS-gE and PS-gE>RNA-gE groups
CMI response induced by 2×RNA-gE or RNA-gE>PS-gE was significantly stronger than 2×PS-gE and PS-gE>RNA-gE
mRNA vaccine showed no observable inflammation at injection sites