Co-Catalyzed Allylic Alcohols

Regioselectivity Controlled

One-step synthesis of allylic alcohols from aqueous formaldehyde enabled by visible-light photoredox and cobalt dual catalysis, with regioselectivity controlled by ligands.

Guo, Ning · Gu, Zheng · Zhu, Meng · Chen, Chen · Xia, Jibao

Angewandte Chemie - International Edition 2025

Advantages

One-step synthesis of linear and branched allylic alcohols

Regioselectivity controlled by ligands

Applicable to terminal and internal alkynes