Activates KRAS oncogenesis
Ubiquitinates KRAS at K128 to activate both wild-type and mutant forms, driving ERK/mTOR/PRELID2/ROS axis in HCC
Xiong, Jun · Yu, Qiang · Zhang, Jie · Fang, Lei · Wu, Di · Lin, Xiao · Xie, Chuanming · Xiong, Haojun
Military Medical Research 2023
FBXL6 is highly expressed in HCC and other human cancers (P < 0.001)
Promotes polyubiquitination of wild-type KRAS and KRASG12D at lysine 128
Dual inhibition of MEK and mTOR effectively suppresses tumor growth and metastasis in vivo