Macrocyclic-Albumin Conjugate

Hypoxia-Responsive Drug Release

Enables precise loading of anticancer drugs via host-guest interactions and site-specific radionuclide labeling, releasing drugs only under hypoxic tumor conditions.

Shujie, Li · Wang, Ying · Wang, Xiaoran · Feng, Jintang · Guo, Dongsheng · Meng, Zhaowei · Liu, Yang · Sun, Shaokai · Zhang, Zhanzhan

ACS Nano 2023

Advantages

Achieves efficient cancer diagnosis and combined radio-chemotherapy in 4T1 tumor-bearing mice