Boosts FOLFOX Efficacy
Anchors thymidylate synthase to stabilize its binding with dUMP, markedly enhancing FOLFOX efficacy against colorectal cancer while reducing renal toxicity.
Shiyao, Song · Tang, Yan · Li, Tang · Ye, Junhong · Huang, Libin · Luo, Xuequn · Chen, Liheng · Qin, Yanlin · He, Weiling
Advanced Materials 2026
significantly enhanced FOLFOX efficacy against colorectal cancer
induced apoptosis, necrosis, cell cycle regulation, DNA damage, and ROS generation
activated immune responses to enhance chemotherapeutic potency
effectively reduced renal toxicity of chemotherapy drugs