Ferroptosis & PTT synergy
Releases Fe/Cu ions in response to the tumor microenvironment, depleting GSH and generating ·OH, synergizing with mild photothermal therapy to induce immunogenic cell death.
Bao, Yujun · Guanghao, Li · Siqi, Li · Haishui, Zhou · Ziqing, Yang · Wang, Zhiqiang · Yan, Rui · Guo, Changhong · Jin, Yingxue
Materials Today Bio 2024
Significantly enhances tumor cell immunogenicity
Effectively downregulates PD-L1 expression on tumor cell surface
Reverses hypoxic tumor microenvironment
Effectively generates ·OH and depletes GSH